Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q96EB6)
Protein (NX_Q96EB6)
Protein
Gene SymbolSIRT1 to neXtProt (NX_Q96EB6)
DescriptionNAD-dependent protein deacetylase sirtuin-1
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of cellular senescence
.negative regulation of cellular senescence
.negative regulation of peptidyl-lysine acetylation
.negative regulation of cellular response to testosterone stimulus
.negative regulation of histone H4-K16 acetylation
.positive regulation of cAMP-dependent protein kinase activity
.negative regulation of cAMP-dependent protein kinase activity
.positive regulation of macrophage apoptotic process
.histone H3-K9 deacetylation
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.negative regulation of protein acetylation
.negative regulation of neuron death
.regulation of cellular response to heat
.stress-induced premature senescence
.cellular response to ionizing radiation
.cellular response to hypoxia
.negative regulation of histone H3-K14 acetylation
.cellular response to tumor necrosis factor
.histone H3 deacetylation
.UV-damage excision repair
.regulation of bile acid biosynthetic process
.cellular response to hydrogen peroxide
.histone H3-K9 modification
.negative regulation of androgen receptor signaling pathway
.fatty acid homeostasis
.negative regulation of protein kinase B signaling
.positive regulation of histone H3-K9 methylation
.negative regulation of helicase activity
.white fat cell differentiation
.positive regulation of insulin receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription, DNA-templated
.negative regulation of gene expression, epigenetic
.positive regulation of DNA repair
.negative regulation of fat cell differentiation
.positive regulation of MHC class II biosynthetic process
.negative regulation of DNA damage response, signal transduction by p53 class mediator
.negative regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
.negative regulation of I-kappaB kinase/NF-kappaB signaling
.negative regulation of apoptotic process
.positive regulation of apoptotic process
.intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.cholesterol homeostasis
.behavioral response to starvation
.response to hydrogen peroxide
.negative regulation of phosphorylation
.regulation of cell proliferation
.regulation of gene expression, epigenetic
.regulation of peroxisome proliferator activated receptor signaling pathway
.cellular triglyceride homeostasis
.peptidyl-lysine deacetylation
.cellular response to heat
.regulation of smooth muscle cell apoptotic process
.regulation of protein import into nucleus, translocation
.circadian regulation of gene expression
.response to insulin
.negative regulation of NF-kappaB transcription factor activity
.regulation of endodeoxyribonuclease activity
.negative regulation of TOR signaling
.positive regulation of chromatin silencing
.protein destabilization
.negative regulation of prostaglandin biosynthetic process
.negative regulation of transforming growth factor beta receptor signaling pathway
.negative regulation of cell growth
.peptidyl-lysine acetylation
.histone deacetylation
.protein ubiquitination
.positive regulation of macroautophagy
.viral process
.regulation of glucose metabolic process
.positive regulation of cholesterol efflux
.negative regulation of gene expression
.gene expression
.cellular response to starvation
.positive regulation of cell proliferation
.cell aging
.muscle organ development
.regulation of mitotic cell cycle
.spermatogenesis
.response to oxidative stress
.cellular response to DNA damage stimulus
.triglyceride mobilization
.protein deacetylation
.rRNA processing
.transcription, DNA-templated
.methylation-dependent chromatin silencing
.maintenance of chromatin silencing
.establishment of chromatin silencing
.chromatin silencing
.chromatin organization
.DNA repair
.DNA replication
.positive regulation of adaptive immune response
.positive regulation of protein phosphorylation
.cellular glucose homeostasis
.ovulation from ovarian follicle
.angiogenesis
.DNA synthesis involved in DNA repair
.pyrimidine dimer repair by nucleotide-excision repair
.chromatin silencing at rDNA
.negative regulation of transcription from RNA polymerase II promoter
.single strand break repair
.keratin filament binding
.NAD+ binding
.mitogen-activated protein kinase binding
.NAD-dependent histone deacetylase activity (H3-K9 specific)
.metal ion binding
.bHLH transcription factor binding
.HLH domain binding
.identical protein binding
.histone binding
.NAD-dependent protein deacetylase activity
.protein deacetylase activity
.enzyme binding
.deacetylase activity
.NAD-dependent histone deacetylase activity
.transcription factor binding
.protein C-terminus binding
.histone deacetylase activity
.transcription corepressor activity
.p53 binding
.core promoter sequence-specific DNA binding
.rDNA heterochromatin
.PML body
.mitochondrion
.cytoplasm
.nucleolus
.nuclear heterochromatin
.nuclear euchromatin
.chromatin silencing complex
.nucleoplasm
.nuclear inner membrane
.nuclear envelope
.nucleus
.nuclear chromatin


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center